Publications by authors named "R Binazzi"
Population Pharmacokinetic and Pharmacodynamic Analysis of Dalbavancin for Long-Term Treatment of Subacute and/or Chronic Infectious Diseases: The Major Role of Therapeutic Drug Monitoring.
Antibiotics (Basel)
July 2022
Article Synopsis
- A population pharmacokinetic analysis of dalbavancin assessed its effectiveness in patients with various infections using non-linear mixed effect modeling and Monte Carlo simulations.
- The study included 69 patients, mostly with bone and joint infections, and found that creatinine clearance was the key factor influencing dalbavancin clearance.
- Results indicated that dosage adjustments based on renal function are crucial, with specific recommendations for single or double doses of 1000 mg or 1500 mg to ensure optimal effectiveness over different time periods.
Article Synopsis
- COVID-19 is a serious respiratory illness caused by the SARS-CoV-2 virus, posing extra risks for patients with chronic autoimmune diseases like pemphigus, which causes blisters on the skin and mucous membranes.
- Pemphigus is treated with immunosuppressants, including rituximab (RTX), which is effective but can increase infection risk due to prolonged B-cell depletion.
- In a specific case, a pemphigus patient experienced severe inflammation from RTX use, but recovered well with corticosteroid treatment, highlighting treatment complexities during the pandemic.
Imported scrub typhus in Europe: Report of three cases and a literature review.
Travel Med Infect Dis
September 2021
Background: Scrub typhus is a vector-borne rickettsial infection, which can cause relevant morbidity and mortality. While the number of cases is around a million per year globally, the infection is seldom diagnosed in travellers from Europe.
Methods: We herein report three cases diagnosed in Italian travellers and review the literature about imported cases in Europe in the last 60 years.
We report a case of a woman who experienced psychiatric disorders after switching her antiretroviral therapy (c-ART) to dolutegravir (DTG). She is a 59-year-old HIV-1 positive woman with a recent story of cardiovascular disorders treated with beta-blockers, clopidogrel, and rosuvastatin. She underwent a c-ART switch from darunavir/cobicistat and maraviroc to emtricitabine/tenofovir alafenamide fumarate in association with dolutegravir due to drug-drug interactions.
View Article and Find Full Text PDFDespite evidence supporting the effectiveness of best practices in infection prevention and management, many healthcare workers fail to implement them and evidence-based practices tend to be underused in routine practice. Prevention and management of infections across the surgical pathway should always focus on collaboration among all healthcare workers sharing knowledge of best practices. To clarify key issues in the prevention and management of infections across the surgical pathway, a multidisciplinary task force of experts convened in Ancona, Italy, on May 31, 2019, for a national meeting.
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