Publications by authors named "R Bijkerk"
Background: Systemic diseases are often associated with endothelial cell (EC) dysfunction. A key function of ECs is to maintain the barrier between the blood and the interstitial space. The integrity of the endothelial cell barrier is maintained by VE-Cadherin homophilic interactions between adjacent cells.
View Article and Find Full Text PDFArticle Synopsis
- Disturbed flow contributes to endothelial dysfunction in intimal hyperplasia, commonly found in vascular grafts, leading to adverse vascular conditions.
- This study introduces a new bypass flow model that simulates disturbed flow and various hemodynamic patterns using pulsatile flow.
- Using computational fluid dynamics (CFD), researchers validated the model by showing that human endothelial cells exposed to disturbed flow exhibited significant changes in morphology and activation compared to cells in regular or stagnant flow, highlighting the model's potential for studying vascular diseases.
Aim: To uncover differences in small non-coding RNAs (sncRNAs) in individuals with type 2 diabetes (T2D) categorized into five clusters based on individual characteristics, which may aid in the identification of those prone to rapid progression.
Materials And Methods: In the Hoorn Diabetes Care System (DCS) cohort, participants were clustered by age, body mass index (BMI), and glycated haemoglobin, C-peptide and high-density lipoprotein (HDL) cholesterol levels, yielding severe insulin-deficient diabetes, severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), mild diabetes, and mild diabetes with high HDL cholesterol clusters (n = 412). Utilizing plasma sncRNA-sequencing, we identified distinct cluster-specific sncRNAs.
Introduction: Micro- and macrovascular complications are common among persons with type 2 diabetes. Recently there has been growing interest to investigate the potential of circulating small non-coding RNAs (sncRNAs) as contributors to the development of diabetic complications. In this study we investigate to what extent circulating sncRNAs levels associate with prevalent diabetic kidney disease (DKD) in persons with type 2 diabetes.
View Article and Find Full Text PDFTGF-β is considered an important cytokine in the development of interstitial fibrosis in chronic kidney disease. The TGF-β co-receptor endoglin (ENG) tends to be upregulated in kidney fibrosis. ENG has two membrane bound isoforms generated via alternative splicing.
View Article and Find Full Text PDF