Publications by authors named "R Biegon"
Over the past few years, a number of studies have revealed that a significant number of men with prostate cancer had genetic defects in the DNA damage repair gene response and mismatch repair genes. Certain of these modifications, notably gene alterations known as homologous recombination (HRR) genes; , , , , and genes for DNA mismatch repair (MMR); , , , and are connected to a higher risk of prostate cancer and more severe types of the disease. The DNA damage repair (DDR) is essential for constructing and diversifying the antigen receptor genes required for T and B cell development.
View Article and Find Full Text PDFArticle Synopsis
- A study in rural Kenya found that 41% of asymptomatic residents had antibodies against the SARS-CoV-2 spike protein, and 82.5% exhibited T cell responses to multiple viral proteins, indicating some level of immunity despite not showing symptoms.
- The immune response profile in Kenyan participants was distinct from those in Europe and Asia, exhibiting strong reactions to accessory proteins rather than structural ones and a unique cytokine balance (higher IL-10 to IFN-γ ratio).
- These findings suggest that current methods of measuring COVID-19 prevalence may underestimate infections in asymptomatic populations, and highlight the potential influence of environmental factors on immune responses in Africa.
Background: Tuberculosis (TB) and HIV co-infections have a global prevalence with devastating morbidity and massive mortality, Sub-Saharan Africa being the worst hit.
Objectives: To evaluate the prevalence of TB-HIV co-infection and demonstrate the confusion caused by NTM and HIV/AIDS co-infection in TB diagnosis and treatment in western Kenya.
Methods: In a cross-sectional study carried out at 10 hospitals in western Kenya, sputa from consenting 872 TB suspects underwent microscopy, and culture on Lowenstein-Jensen and Mycobacteria Growth Index Tube media.
Fluorescent dyes are commonly used to study permeable (gap) junctions, but only rarely have quantitative values for junctional dye permeability been determined. In the present study, junctional permeance (PA, i.e.
View Article and Find Full Text PDFMethylisobutylxanthine (MIX) augmented contractions and Ca++-dependent action potentials in ventricles isolated from embryonic and hatched chicks. Acetylcholine (ACh) inhibited these effects of MIX. In ventricles from chicks on the 18th incubation day, cyclic AMP content was increased to about 150% of basal after 3 min in 3 X 10(-4) M MIX.
View Article and Find Full Text PDF