HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism.

Acute Myeloid Leukemia (AML) are challenging blood cancers with limited long-term survival rates, necessitating novel therapeutic strategies. This study explored the role of Histone deacetylase (HDAC) inhibitors in enhancing ferroptosis in AML cells by modulating iron metabolism. We demonstrated that HDAC inhibitors (Entinostat and Vorinostat) sensitize AML cells to ferroptosis both in vitro and in vivo.

Multimaterial cryogenic printing of three-dimensional soft hydrogel machines.

Hydrogel-based soft machines are promising in diverse applications, such as biomedical electronics and soft robotics. However, current fabrication techniques generally struggle to construct multimaterial three-dimensional hydrogel architectures for soft machines and robots, owing to the inherent hydrogel softness from the low-density polymer network nature. Herein, we present a multimaterial cryogenic printing (MCP) technique that can fabricate sophisticated soft hydrogel machines with accurate yet complex architectures and robust multimaterial interfaces.

Analysis of carbon reduction potential from typical municipal solid waste incineration plants under MSW classification.

The disposal of municipal solid waste (MSW) is a significant source of greenhouse gas (GHG) emissions. As incineration becomes the primary method of MSW disposal in China, MSW incineration (MSWI) plants are expected to play a crucial role in mitigating GHG emissions in the waste sector. This study estimated the quarterly GHG emissions from two representative MSWI plants in Qingdao using a life-cycle assessment (LCA) approach.

Evidence of sewage discharge on the coalescence mechanism of aquatic microbial communities during high amplitude hydrological periods.

Microbial community coalescence is a ubiquitous ecological process in various ecosystems. However, limited research has addressed the effects of the coalescence on microbial ecological processes and network structure, particularly in the context of sewage discharge during high amplitude hydrological periods. Employing 16S rRNA sequencing and species source tracking analysis, we investigated the coalescence pattern of bacterioplankton in the Chishui river and sewage across various hydrological periods.

Differences in soil Cd immobilization and blockage of rice Cd uptake by biochar derived from crop residue and bone - A 2-year field experiment.

Biochar is widely recognized as an effective amendment for soils contaminated with cadmium (Cd). However, the properties and elemental compositions of biochar derived from different feedstocks may significantly impact the transfer of Cd in the soil-rice system. This study conducted a two-year field trial in Cd-contaminated paddy soil.