Publications by authors named "R Bhati"
Article Synopsis
- This study investigates potential drug targets in a pathogenic bacterium commonly found in the gastrointestinal tract, which poses a risk of infections and has rising antibiotic resistance.
- Using a subtractive proteomics approach, the researchers identified essential proteins and metabolic pathways linked to both the pathogen and its host to reduce side effects of new treatments.
- The study highlights MurM, a key protein involved in bacterial cell wall synthesis, as a promising drug target and identified several lead candidates for further development to combat antibiotic resistance.
Supported liquid membrane (SLM) incorporating ionic liquids (ILs) or deep eutectic solvents (DESs) offers a promising method for ion and (bio)chemical separations and CO capture. However, a molecular understanding of whether chemical reactions occur in these confined media is crucial. We report excited-state proton transfer (ESPT) reaction of a photoacid, HPTS, in various DES-based SLMs (pore size ∼280 nm) using steady-state and time-resolved fluorescence spectroscopy.
View Article and Find Full Text PDFSARS-CoV-2 infections before, during, and after the Omicron wave: a 2-year Indian community cohort study.
Lancet Reg Health Southeast Asia
September 2024
Background: We measured the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and re-infections in an adult community-based cohort in southern India.
Methods: We conducted a 2-year follow-up on 1229 participants enrolled between May and October 2021. Participants provided vaccination histories, weekly saliva samples, and blood samples at 0, 6, 12, and 24 months.
Article Synopsis
- Warfarin is a cardiovascular drug that interacts strongly with lysozyme, primarily through hydrophobic forces, with temperature increasing the degree of binding.
- Experimental results revealed that while low concentrations of warfarin don't affect lysozyme's secondary structure, higher concentrations can lead to partial unfolding.
- Computational methods, including molecular docking and dynamics, confirmed stable binding and structural changes in lysozyme induced by warfarin, emphasizing its role in hydrogen bonding without drastically altering protein conformation.
Digitoxin is a cardiac glycoside used to treat heart failure and heart arrhythmia. However, its therapeutic concentration range is very narrow. High doses of digitoxin are associated with severe side effects; therefore, it is necessary to develop the delivery system which can control the plasma levels of it.
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