Automated Lesion and Feature Extraction Pipeline for Brain MRIs with Interpretability.

This paper introduces the Automated Lesion and Feature Extraction (ALFE) pipeline, an open-source, Python-based pipeline that consumes MR images of the brain and produces anatomical segmentations, lesion segmentations, and human-interpretable imaging features describing the lesions in the brain. ALFE pipeline is modeled after the neuroradiology workflow and generates features that can be used by physicians for quantitative analysis of clinical brain MRIs and for machine learning applications. The pipeline uses a decoupled design which allows the user to customize the image processing, image registrations, and AI segmentation tools without the need to change the business logic of the pipeline.

Getting it right: suppression and leveraging of noise in robust decision-making.

Noise is a ubiquitous feature for all organisms growing in nature. Noise (defined here as stochastic variation) in the availability of nutrients, water and light profoundly impacts their growth and development. Not only is noise present as an external factor but cellular processes themselves are noisy.

Effectiveness of Eupatorium Perfoliatum 30C in Preventing Dengue Fever-A Prospective, Community-Based, Open Label, Parallel Cohort Study in Delhi, India.

Objective:  The study was undertaken to evaluate the protective effect of (EP) 30C on the incidence of dengue fever.

Design:  This study was designed as a prospective, open label, parallel cohort study.

Interventions:  Participants were enrolled in two medicine cohort (MC) communities and one control cohort (CC) community.

TYPHON proteins are RAB-dependent mediators of the trans-Golgi network secretory pathway.

The trans-Golgi network (TGN), a key compartment in endomembrane trafficking, participates in both secretion to and endocytosis from the plasma membrane. Consequently, the TGN plays a key role in plant growth and development. Understanding how proteins are sorted for secretion or endocytic recycling at the TGN is critical for elucidating mechanisms of plant development.