Publications by authors named "R Beyrouthy"
Article Synopsis
- The PACIFIC study examined the presence of Adherent-Invasive E. coli (AIEC) in Crohn's disease patients from France and Hong Kong, finding similar prevalence rates (24.5% in France vs. 30.0% in Hong Kong).
- Antibiotic resistance was notably higher in AIEC strains from Hong Kong, particularly against multiple antibiotics, compared to those from France.
- All AIEC strains from both regions showed sensitivity to an EcoActive™ phage cocktail, indicating potential for this treatment to be effective globally against AIEC in Crohn's disease.
Pseudomonas aeruginosa demonstrates a remarkable capacity for adaptation and survival in diverse environments. Furthermore, its clinical importance is underscored by its intrinsic and acquired resistance to a wide range of antimicrobial agents, posing a substantial challenge in healthcare settings. Amidst this complex landscape of resistance, the Type VI Secretion System (T6SS) in P.
View Article and Find Full Text PDFMAST® D72C test: a novel option for ESBL, AmpC and carbapenemase detection.
Eur J Clin Microbiol Infect Dis
June 2024
Purpose: The MAST® D72C test is a phenotypical test which can detect ESBL and AmpC production in Enterobacterales. It can also identify the suspected presence of carbapenemase. The aim of the present study was to assess the sensitivity and specificity of this test and to discuss its usefulness in laboratories, especially those that use only an automated AST system.
View Article and Find Full Text PDFArticle Synopsis
- Extended-spectrum cephalosporins (ESCs) are crucial antimicrobials used to combat multidrug-resistant (MDR) bacterial infections, but resistance against them is rising, mainly due to certain β-lactamases produced by Enterobacterales.
- This study focused on analyzing Escherichia coli strains with resistance genes collected from Canada, France, and Germany over a 14-year period, employing advanced sequencing techniques to examine the transmission of these resistance genes via plasmids.
- Five distinct plasmid subtypes linked to the spread of ESC resistance genes were identified, with varying prevalence across geographic regions and host species, highlighting the role of plasmid diversity in the global issue of antibiotic resistance.
Colorectal cancer (CRC) patients are frequently colonized by colibactin-producing (CoPEC) (>40%), which enhances tumorigenesis in mouse models of CRC. We observed that 50% of CoPEC also contains the gene, which encodes cytotoxic necrotizing factor-1 (CNF1), an enhancer of the eukaryotic cell cycle. The impact of its co-occurrence with colibactin (Clb) has not yet been investigated.
View Article and Find Full Text PDF