Publications by authors named "R Bertinchamp"
Article Synopsis
- Data on the effectiveness of mTOR inhibitors in treating autoimmune cytopenia (AIC) in adults is limited, prompting a study of 30 cases who received mTORi-based therapy.
- The study found that a significant portion of patients, particularly those with multilineage AIC, showed positive responses, with 73% of patients responding to treatment, including 57% achieving complete response.
- Overall, mTORi may serve as a viable alternative or supplementary treatment for adults with refractory or relapsing AIC, especially beneficial for those with multilineage conditions.
Castleman disease is a group of rare disorders characterized by lymph node enlargement, specific microscopic changes to the lymph nodes, and a broad range of symptoms and laboratory findings. The two main subtypes are unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD). The multicentric subtype can be further classified into two categories: HHV-8 positive multicentric Castleman disease and idiopathic multicentric Castleman disease (iMCD).
View Article and Find Full Text PDFKaposi sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8-associated multicentric Castleman disease (MCD) is a polyclonal B-cell lymphoproliferative disorder that mainly occurs in immunocompromised hosts. The diagnosis relies on lymph node biopsy demonstrating KSHV-infected cells located in the mantle zone with a marked interfollicular plasma cell infiltration. Infected cells are large cells positive for immunoglobulin M (IgM), λ light chain, and CD38, described initially as infected plasmablasts.
View Article and Find Full Text PDFArticle Synopsis
- Inborn errors of immunity (IEI) are complex conditions that often lead to late diagnoses, with a rise in related inflammatory issues alongside infections.
- A case study of an adult showed that chronic Human Adenovirus C-1 arthritis was diagnosed in a patient with primary agammaglobulinemia, highlighting the challenges in managing these patients.
- The use of metagenomic next-generation sequencing provided an accurate diagnosis, and high-dose intravenous immunoglobulins led to complete recovery, emphasizing the need for advanced diagnostic techniques in treating immune-compromised individuals.