Publications by authors named "R Berthaud"
Article Synopsis
- The human immune system continues to develop for several years after birth, affecting how young children respond to infections, such as SARS-CoV-2.
- Researchers studied T cell responses in children and adults before, during, and after SARS-CoV-2 infection, revealing that younger children (under 5) had a weaker CD4 T cell response compared to older children and adults with mild disease.
- Following infection, preschool-age children produced similar neutralizing antibodies to adults but had different T cell characteristics and fewer memory B cells, indicating a gradual maturation of their adaptive immune responses.
Article Synopsis
- A study on the pharmacokinetics of lumacaftor/ivacaftor in children with cystic fibrosis (CF) highlights the importance of optimizing treatment based on individual differences.
- Factors like body weight and liver function were found to significantly affect drug levels in patients, showing that each child may process the medication differently.
- The research suggests that personalized dose adjustments and therapeutic drug monitoring could enhance treatment effectiveness in this vulnerable population.
Background: Neonatal renal vein thrombosis (NRVT) is a rare condition with little data available.
Methods: We retrospectively analyzed newborns diagnosed with NRVT admitted to 3 pediatric nephrology units in Paris from 2005 to 2020.
Results: Twenty-seven patients were analyzed (male = 59%).
We aimed to develop a piperacillin population pharmacokinetic (PK) model in critically ill children receiving continuous renal replacement therapy (CRRT) and to optimize dosing regimens. The piperacillin plasma concentration was quantified by high-performance liquid chromatography. Piperacillin PK was investigated using a nonlinear mixed-effect modeling approach.
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