Publications by authors named "R Basaran"
Objective: This research aims to assess the clinical and radiological outcomes of both dynamic rod system (PLSDR) and rigid rod system (PLSRR) when treating lumbar degenerative disease (LDD).
Method: A retrospective review of 98 patients who underwent posterior stabilization surgery with a posterior approach in our clinic between 2018 and 2023 was conducted. The patients were divided into two groups based on the type of implant used: Those with PLSRR (Group 1) and those with PLSDR (Group 2).
Background: Speech changes significantly impact the quality of life for Parkinson's disease (PD) patients. Deep Brain Stimulation (DBS) of the Subthalamic Nucleus (STN) is a standard treatment for advanced PD, but its effects on speech remain unclear. This study aimed to investigate the relationship between STN-DBS and speech changes in PD patients using comprehensive clinical assessments and tractography.
View Article and Find Full Text PDFArticle Synopsis
- Multivalent lectin-glycan interactions (MLGIs) play a key role in viral infections and immune response, making understanding their structure essential for developing new therapies.
- Researchers have created glycosylated nanoparticles, specifically gold nanoparticles (GNPs), to study MLGIs and have established a method to assess their binding affinities and structural characteristics.
- Findings indicate that larger GNPs enhance MLGI affinity and antiviral effectiveness, particularly a 27 nm GNP that significantly inhibits viral connections to the DC-SIGN receptors.
The dendritic cell tetrameric lectin, DC-SIGN, and its closely related endothelial cell lectin, DC-SIGNR (collectively abbreviated as DC-SIGN/R) play a key role in the binding and transmission of deadly viruses, including Ebola, HIV, HCV, and SARS-CoV-2. Their virus binding/release processes involve a gradually acidifying environment following the natural intracellular trafficking pathways. Therefore, understanding DC-SIGN/R's pH-dependent binding properties with glycan ligands is of great importance.
View Article and Find Full Text PDFBackground: Postoperative pain following posterior fixation is caused not only by tissue injury during surgery and is related to inflammatory, neuropathic, and visceral pain. This study aims to answer the question, "Is there a role for gabapentinoids in reducing postoperative pain?" In addition, it demonstrates which gabapentinoids may be used, for how long, and at what dose.
Methods: The study was planned as a prospective, randomized, double-blind study.