Publications by authors named "R Bartolini"
Article Synopsis
- The study identifies biomarkers that can differentiate between immune-related cytokine release syndrome (irCRS) and sepsis in oncology patients undergoing immune checkpoint inhibitor therapy.
- The analysis revealed that hepatocyte growth factor (HGF) and ferritin are particularly effective in predicting outcomes related to irHLH and Grade 3 irCRS, with a 100% positive and negative predictive value.
- Patients with severe irCRS who did not respond to corticosteroids showed complete resolution after treatment with tocilizumab (TCZ), highlighting the potential for targeted therapies in these cases.
Article Synopsis
- The article discusses the coexpression of CCR1 and CCR2 on monocytes, highlighting that this combination is essential in identifying a unique subpopulation of these immune cells.
- The authors acknowledge that Fabian Schuette was omitted from the initial author list and have corrected this oversight in the online version of the article.
- The research was conducted by a team from the Chemokine Research Group at the University of Glasgow, focusing on the role of chemokines in immune response.
Article Synopsis
- Prostate cancer (PCa) has an immunosuppressive environment that limits immune activation, resulting in reduced activity of cytotoxic T-cells and increased levels of regulatory T cells (Tregs) and tumor-associated macrophages (TAMs), which are linked to poorer outcomes.
- The review emphasizes the role of different immune cells, including beneficial Th1 and harmful Th17 cells, in influencing tumor behavior, and how PCa's low immunogenicity poses challenges for immunotherapy.
- Chemotherapy is shown to have the potential to enhance the immune response against tumors by transforming the "cold" tumor microenvironment into a "hot" one, improving treatment efficacy by targeting immunosuppressive cells.
Article Synopsis
- This study evaluated the effectiveness of tocilizumab (TCZ) for treating arthritis caused by immune checkpoint inhibitors (ICI-AR) and preventing relapses during ICI treatment reassignment.
- Researchers analyzed data from 26 patients, finding that all patients treated with TCZ had significant improvement in their arthritis symptoms and many achieved remission without steroids after 24 weeks.
- The results indicated that using TCZ as a preventive measure during ICI rechallenge significantly reduced relapse rates and extended ICI treatment duration compared to patients not receiving TCZ.
Duddingtonia flagrans is a nematode trapping fungus used for the control of gastrointestinal nematodes in livestock. The quantity of chlamydospores of D. flagrans required for the reduction of third-stage larvae (L3) of sheep gastrointestinal nematodes (GIN) is largely unknown, and a matter of discussion.
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