Publications by authors named "R Bartenschlager"
Article Synopsis
- * An analysis of 1,192 participants revealed elevated sACE2 activity following exposure to SARS-CoV-2, especially in children, indicating a significant response regardless of infection status.
- * The research suggests that increased sACE2 activity could help manage SARS-CoV-2 infections, proposing a more nuanced understanding of immune responses beyond traditional infection classifications.
Article Synopsis
- * The study introduces a novel counter-selection method using phage display to identify covalent macrocyclic ligands that can disrupt protein-protein interactions, specifically targeting the SARS-CoV-2 Spike-ACE2 interaction.
- * The identified covalent inhibitors showed strong antiviral effects, demonstrating their permanence due to the covalent binding mechanism, highlighting the potential for developing long-lasting drugs that interfere with critical protein interactions.
The replication organelle of hepatitis C virus (HCV), called membranous web, is derived from the endoplasmic reticulum (ER) and mainly comprises double membrane vesicles (DMVs) that concentrate the viral replication complexes. It also tightly associates with lipid droplets (LDs), which are essential for virion morphogenesis. In particular acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a rate-limiting enzyme in triglyceride synthesis, promotes early steps of virus assembly.
View Article and Find Full Text PDFWe recently showed that an adapted SARS-CoV-2 vaccine with wildtype and BA.4/BA.5 Omicron subtype epitopes induced a broad short-term immune response in hemodialysis patients.
View Article and Find Full Text PDFArticle Synopsis
- Dengue fever poses a major health and economic challenge in (sub)tropical regions, with no antiviral treatments currently available.
- JNJ-A07 has been shown to be effective against various dengue virus genotypes by targeting the viral non-structural protein 4B (NS4B) and disrupting important interactions needed for viral replication.
- This research clarifies how JNJ-A07 and a similar compound, NITD-688, inhibit the formation of vesicle packets crucial for dengue virus RNA replication, offering new insights into potential antiviral strategies.