Publications by authors named "R Barre"
The host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States (US). Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the cattle-origin influenza A/bovine/Texas/24-029328-02/2024(H5N1, rHPbTX) and A/Texas/37/2024(H5N1, rHPhTX) viruses, identified in dairy cattle and human, respectively, and their low pathogenic forms, rLPbTX and rLPhTX, with monobasic HA cleavage sites.
View Article and Find Full Text PDFSince the emergence of highly pathogenic avian influenza virus (HPAIV) H5N1 of clade 2.3.4.
View Article and Find Full Text PDFThe study of immune phenotypes in wild animals is beset by numerous methodological challenges, with assessment of detailed aspects of phenotype difficult to impossible. This constrains the ability of disease ecologists and ecoimmunologists to describe immune variation and evaluate hypotheses explaining said variation. The development of simple approaches that allow characterization of immune variation across many populations and species would be a significant advance.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how genetics and environment together affect immune responses in mice, focusing on three different inbred strains (C57BL/6, 129S1, PWK/PhJ) in an outdoor setting and infected with a specific parasite.
- - It finds that while the overall structure of immune cells is influenced by both genetics and the environment, the variation in certain immune responses, like cytokine levels, is mainly determined by genetics, affecting how many parasites the mice carry.
- - Additionally, the expression of immune markers like CD44 shows different influences: on T cells, it’s mostly genetic, while on B cells, it’s more environmental; and importantly, the impact of genetics appears to lessen when the mice
Background: The continuous evolution of drug-resistant influenza viruses highlights the necessity for repurposing naturally-derived and safe phytochemicals with anti-influenza activity as novel broad-spectrum anti-influenza medications.
Methods: In this study, nitrogenous alkaloids were tested for their viral inhibitory activity against influenza A/H1N1 and A/H5N1 viruses. The cytotoxicity of tested alkaloids on MDCK showed a high safety range (CC > 200 µg/ml), permitting the screening for their anti-influenza potential.