Long-Term Patient Satisfaction and Surgical Outcomes With Sophono Implants: A Single-Institution Experience.

Objectives Percutaneous and transcutaneous bone conduction hearing implants are used in various otological conditions. This study aimed to evaluate patient satisfaction with Sophono implants and their long-term surgical outcomes. Methods This retrospective study was conducted at Queen Elizabeth Hospital, Birmingham, between October 2022 and May 2023.

Evaluation of Clinical Performance of Ponto Implantation Using a Minimally Invasive Surgical Technique-A Prospective Multicenter Study.

Objective: To investigate the clinical outcomes of bone-anchored hearing implant surgery using the MONO procedure.

Study Design: Multicenter, multinational, single-arm, prospective trial with a 12-month follow-up.

Setting: Seven European university hospitals from the United Kingdom, Sweden, Denmark, and The Netherlands.

The multifaceted nature of HIV tissue reservoirs.

Purpose Of Review: To underline the complexity and the heterogeneity of the HIV reservoir.

Recent Findings: While lymphoid tissues (spleen, lymph nodes, gut-associated lymphoid tissue) harbor specific subsets of specialized CD4 +  T cells enriched in HIV-infected cells, non-CD4 +  T cell reservoirs such as tissue-resident macrophages and dendritic cells have also been implicated to contribute to viral persistence. Moreover, studies have applied highly sensitive tools to detect transcriptional activity within HIV-infected cells during prolonged ART and revealed a broader spectrum of transcriptional activity for proviruses than previously thought.

Management and mechanism of calciphylaxis in a patient treated with the FGFR inhibitor pemigatinib-a case report.

Background: Small molecule fibroblast growth factor receptor (FGFR) inhibitors, such as pemigatinib, have been developed for the treatment of cholangiocarcinoma (CCA) with rearrangements or fusions in the FGFR2. FGFR inhibitors (FGFRis) have dermatologic side effects such as dry skin or nail bed damage. However, in very rare instances, a life-threatening vascular calcification disease known as calciphylaxis has been linked to these therapies.

Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART.

Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) in HIV persistence has long been limited to the blood due to difficulties to access lymphoid tissue samples. In this study, we show that LN migratory and resident DC subpopulations harbor distinct phenotypic and transcriptomic profiles. Interestingly, both LN DC subpopulations contain HIV intact provirus and inducible replication-competent HIV despite the expression of the antiviral restriction factor SAMHD1.