Publications by authors named "R Baliga"
Article Synopsis
- - Cardiomyocyte-derived C-type natriuretic peptide (CNP) plays a vital role in heart health by regulating blood flow and heart function, with its effects becoming crucial during myocardial infarction (MI).
- - Studies on mice showed that those lacking CNP had larger heart damage after MI and worse long-term heart function, while those given CNP treatment showed improvements.
- - The research suggests that CNP serves as an important protective response from heart cells after an MI, primarily working through a specific receptor (NPR-C), indicating its potential as a new treatment for heart attacks.
Article Synopsis
- Many kidney transplant patients are classified as having no rejection after biopsy, but some may actually have undetected rejection activities.
- A study of over 5,000 biopsies found that more than half were marked as no rejection, yet many showed signs of subthreshold T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR).
- Patients with these hidden rejection activities are at increased risk of future graft issues, as higher levels of TCMR and ABMR correlate with worse kidney function and higher chances of rejection in subsequent biopsies.
NKX2-5 is a member of the homeobox-containing transcription factors critical in regulating tissue differentiation in development. Here, we report a role for NKX2-5 in vascular smooth muscle cell phenotypic modulation in vitro and in vascular remodeling in vivo. NKX2-5 is upregulated in scleroderma patients with pulmonary arterial hypertension.
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