Publications by authors named "R Balana-Fouce"
Article Synopsis
- * The study focused on developing a larval migration inhibition assay to test the effectiveness of various commercial drugs and new derivatives against Strongyloides ratti larvae.
- * Results showed that while ivermectin had high effective concentrations, some new derivatives outperformed it in inhibiting larval motility, suggesting they could be viable alternatives for treating strongyloidiasis.
Article Synopsis
- Visceral leishmaniasis, caused by the trypanosomatid parasite, is treated with outdated drugs that often lead to resistance and side effects.
- Drug repurposing is being explored to find new treatments, with promising results from nitroaromatic compounds like fexinidazole and pretomanid, which have shown effectiveness against leishmaniasis in various studies.
- Recent tests using a high-throughput screening platform demonstrated that these nitroimidazoles are effective against parasite cells while causing minimal harm to human cell cultures, suggesting they may disrupt thiol metabolism rather than inhibit key enzymes directly.
Infectious diseases caused by trypanosomatids, including African trypanosomiasis (sleeping sickness), Chagas disease, and different forms of leishmaniasis, are Neglected Tropical Diseases affecting millions of people worldwide, mainly in vulnerable territories of tropical and subtropical areas. In general, current treatments against these diseases are old-fashioned, showing adverse effects and loss of efficacy due to misuse or overuse, thus leading to the emergence of resistance. For these reasons, searching for new antitrypanosomatid drugs has become an urgent necessity, and different metabolic pathways have been studied as potential drug targets against these parasites.
View Article and Find Full Text PDFLeishmaniasis in wild canids is a vector-borne disease caused in Europe by the protozoan parasite . To date, there is limited information on clinical signs and laboratory abnormalities in wolves due to leishmaniasis. The current clinical case report described a female Iberian wolf () housed in semi-captivity conditions at the Centro del Lobo Ibérico "Félix Rodríguez de la Fuente", in Robledo de Sanabria, Zamora (Spain), with an interdigital ulcerous wound at the right forepaw, hyper-gammaglobulinemia, and abnormal liver blood parameters.
View Article and Find Full Text PDFReportedly, synthetic drugs such as metronidazole, furazolidone, tinidazole, and quinacrine are used for the treatment of giardiasis but are associated with adverse effects. In this study, we aimed to investigate the in vitro and in vivo effects of eucalyptol (ECT, 1,8 cineole) alone and in combination with metronidazole (MNZ) on Giardia lamblia. The effects of ECT on cell viability, plasma membrane permeability, and gene expression levels of adenylate cyclase (AK) and extracellular signal kinases 1 and 2 (ERK1 and ERK2) in trophozoites of G.
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