Publications by authors named "R Balagurunathan"
Article Synopsis
- A bioactive yellow-red pigment from *Streptomyces kunmingensis* was isolated and characterized, showing strong anti-infective properties against MRSA and Mycobacterium tuberculosis.
- The pigment, a chromopeptide with a specific chemical formula, was identified using various spectral analyses and exhibited antibacterial effects against Staphylococcus aureus as well as antiproliferative effects on 14 human cancer cell lines.
- Additionally, it demonstrated effective wound-healing properties in a rat model, highlighting its potential for antimicrobial, wound-healing, and anticancer applications.
Article Synopsis
- - The research focuses on creating a sustainable and cost-effective biographene using metabolites from actinobacteria linked to mushrooms to reduce graphene oxide (GO) in an environmentally friendly way.
- - Key findings showed that the metabolites from *Streptomyces achromogenes* effectively converted nano-GO into reduced graphene oxide (rGO), demonstrating low toxicity and potential for bone regeneration with no harmful effects on liver and kidney tissues observed.
- - The results indicate that biographene has promising biomedical applications, addressing significant health and environmental issues, highlighting its potential for future research and use.
The increasing concern over multidrug resistance in pathogens has led to an ongoing search for novel antibiotics derived from soil actinobacteria. In this current investigation, actinobacteria were isolated from the rhizosphere of bamboo plants collected within the Megamalai forest of the Western Ghats in the Theni zone of Tamil Nadu, India. These actinobacteria were subjected to characterization, and their growth conditions were optimized to enhance the production of bioactive compounds.
View Article and Find Full Text PDFThis study involves the in-vitro and in-vivo anti-TB potency and in-vivo safety of Transitmycin (TR) (PubChem CID:90659753)- identified to be a novel secondary metabolite derived from Streptomyces sp (R2). TR was tested in-vitro against drug resistant TB clinical isolates (n = 49). 94% of DR-TB strains (n = 49) were inhibited by TR at 10μg ml-1.
View Article and Find Full Text PDFChicken feather meal has had a significant biofertilizer approach in recent years. The current study aims to assess feather biodegradation to promote plant and fish growth. The Geobacillus thermodenitrificans PS41 strain was more efficient in feather degradation.
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