Lauric acid-loaded biomimetic, biocompatible, and antioxidant jelly fig (Ficus awkeotsang Makino) pectin hydrogel accelerates wound healing in diabetic rats.

Herein, we have presented a lauric acid (LA)-loaded jelly fig pectin (JFP)-based biocompatible hydrogel, which possesses strong antioxidant and antibacterial properties to treat diabetic wounds. The antioxidant and antibacterial activity of the JFP + LA hydrogels were beneficial in eliminating the reactive oxygen species (ROS) and bacterial infection in the wound bed, thereby protecting the wound surface and accelerating the tissue repair process. The in vivo diabetic wound healing studies demonstrated that applying JFP + LA hydrogels improved the rate of wound contraction and reduced the epithelialization time significantly.

Development and validation of a novel tool to measure tear volume in volumetric unit (microlitre) per minute "the standard international unit (SI) tear strip".

The Schirmer strip measures tear volume in millimeters. A major limitation of the Schirmer strip is that it does not measure tear volume in a volumetric unit. Furthermore, the linearity range, lower limit of detection (LLOD), and lower limit of quantification (LLOQ) are not established.

An Illustrative Approach to Removing Conjunctival Bitten Ant Foreign Body.

An animate ocular foreign body poses a challenging situation for the ophthalmologist for its complete removal. Incomplete removal may lead to infection and inflammation. A woman in her 50s presented with a history of an ocular foreign body in her left eye while working in the agricultural land.

Brønsted acid-promoted synthesis of highly functionalized tetrahydrocarbazoles from diethyl ()-5-diazo-4-oxohex-2-enedioate.

Brønsted acid-promoted synthesis of highly functionalized tetrahydrocarbazoles from indoles and easily accessible diethyl ()-5-diazo-4-oxohex-2-enedioate has been achieved. Diethyl ()-5-diazo-4-oxohex-2-enedioate acts as a 1,4-diacceptor and undergoes tandem Michael addition followed by nucleophilic substitution at the diazo carbon with indole in the presence of a strong Brønsted acid.