Tailoring Kidney Transplant Strategies: Unraveling the Impact of Acute Kidney Injury and Preservation Methods Across Different Strata of Kidney Risk.

Background: The use of donor kidneys with acute kidney injury (AKI) aims to expand the organ pool, but uncertainty remains regarding their outcomes across different Kidney Donor Profile Index (KDPI) groups and preservation methods.

Methods: We retrospectively analyzed 108 160 deceased donor kidney transplants from the OPTN database, focusing on adult recipients of kidneys from donors with or without AKI between December 2014 and December 2022. Propensity matching was used for each KDPI group (1-20, 21-59, 60-84, and 85-100), comparing donors with AKIN stages 0-1 to AKIN stages 2-3.

Highly sensitized patients listed for heart after liver transplantation with or without domino.

For patients with end-stage heart disease and borderline hemodynamics, high human leukocyte antigen allosensitization presents a barrier to heart transplantation in a timely manner. Conventional desensitization protocols are inadequate in this context due to time constraints and for the most highly reactive immunologically. We previously reported performing heart after liver transplant with domino liver transplant on a single patient without liver disease.

Discerning the Structure-Photophysical Property Correlation in Zero-Dimensional Antimony(III)-Doped Indium(III) Halide Hybrids.

Zero-dimensional (0D) metal halide hybrids incorporating optically emissive Sb dopants have received huge research attention as a result of dopant-based visible emission for lighting and scintillation applications. Indeed, there have been a plethora of reports on Sb doping of indium halide (In-X)-based 0D hybrids that show strong dopant emission with varied emission wavelengths (λ) and photoluminescence quantum yields (PLQYs). However, discerning the structure-luminescence relation in these 0D-doped hybrids remains challenging because it necessitates exquisite synthetic control on the local metal (dopant) halide geometry/site asymmetry.

Development and First Clinical Use of an Extracorporeal Artificial Multiorgan System in Acute-on-Chronic Liver Failure Patients.

Multiple organ failure (MOF) is a common and deadly condition. Patients with liver cirrhosis with acute-on-chronic liver failure (AOCLF) are particularly susceptible. Excess fluid accumulation in tissues makes routine hemodialysis generally ineffective because of cardiovascular instability.