Publications by authors named "R Bainton"

Article Synopsis
  • The study investigates how the plasma from COVID-19 patients affects platelet behavior and how the released contents from these platelets impact neutrophils, both of which are involved in thromboinflammatory responses associated with the disease.
  • Researchers treated platelets with plasma from COVID-19 patients and healthy controls, measuring their aggregation and adhesion, and exposed neutrophils to the releasate from COVID-19 platelets for further analysis of inflammatory responses.
  • Findings showed that COVID-19 plasma promotes platelet auto-aggregation, reducing their response to stimulation, and that platelet releasate from COVID-19 patients enhances neutrophil activity, suggesting that the plasma environment plays a significant role in altering these cells
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Autopsy and biomarker studies suggest that endotheliopathy contributes to coronavirus disease (COVID-19)-associated acute respiratory distress syndrome. However, the effects of COVID-19 on the lung endothelium are not well defined. We hypothesized that the lung endotheliopathy of COVID-19 is caused by circulating host factors and direct endothelial infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Background: The earliest measurable changes to postinjury platelet biology may be in the platelet transcriptome, as platelets are known to carry messenger ribonucleic acids (RNAs), and there is evidence in other inflammatory and infectious disease states of differential and alternative platelet RNA splicing in response to changing physiology. Thus, the aim of this exploratory pilot study was to examine the platelet transcriptome and platelet RNA splicing signatures in trauma patients compared with healthy donors.

Methods: Preresuscitation platelets purified from trauma patients (n = 9) and healthy donors (n = 5) were assayed using deep RNA sequencing.

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Introduction: The ongoing SARS-CoV-2 pandemic has spurred the development of numerous point of care (PoC) immunoassays. Assessments of performance of available kits are necessary to determine their clinical utility. Previous studies have mostly performed these assessments in a laboratory setting, which raises concerns of translating findings for PoC use.

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Background: Altered postinjury platelet behavior is recognized in the pathophysiology of trauma-induced coagulopathy (TIC), but the mechanisms remain largely undefined. Studies suggest that soluble factors released by injury may inhibit signaling pathways and induce structural changes in circulating platelets. Given this, we sought to examine the impact of treating healthy platelets with plasma from injured patients.

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