Publications by authors named "R Baier"
Article Synopsis
- Influenza vaccination is crucial to prevent illness and death in nursing home residents, and this study compares the effectiveness of recombinant influenza vaccine versus standard-dose vaccines in this population.
- Conducted across two influenza seasons, the study randomized nursing homes to administer either the recombinant quadrivalent vaccine or the standard vaccine, focusing on residents aged 65 and older.
- The main outcome measured was respiratory-related hospitalization rates, while secondary outcomes included overall mortality and hospitalization for any reason, with a substantial sample size of over 144,000 observations.
Article Synopsis
- SARS-CoV-2 vaccinations have decreased hospitalization and death rates in nursing home residents, but effectiveness is challenged by new variants and reduced immunity.
- A study evaluated the immune response to the XBB.1.5 monovalent vaccine in nursing home residents and healthcare workers, focusing on those with prior infections.
- Results showed a significant increase in neutralizing antibody levels, especially in nursing home residents who had a previous infection, indicating the vaccine's ability to enhance immunity against Omicron variants.
Background: Inequities in health access and outcomes exist between Indigenous and non-Indigenous populations. Embedded pragmatic randomized, controlled trials (ePCTs) can test the real-world effectiveness of health care interventions. Assessing readiness for ePCT, with tools such as the Readiness Assessment for Pragmatic Trials (RAPT) model, is an important component.
View Article and Find Full Text PDFThe National Institute on Aging Alzheimer's Disease/Alzheimer's Disease and Related Dementias Research Implementation Milestones emphasize the need for implementation research that maximizes up-take and scale-up of evidence-based dementia care practices across settings, diverse populations, and disease trajectories. Organizational readiness for implementation is a salient consideration when planning and conducting embedded pragmatic trials, in which interventions are implemented by provider staff. The current article examines the conceptual and theoretical underpinnings of organizational readiness for implementation and the operationalization of this construct.
View Article and Find Full Text PDFBackground: SARS-CoV-2 vaccination has reduced hospitalization and mortality for nursing home residents (NHRs). However, emerging variants coupled with waning immunity, immunosenescence, and variability of vaccine efficacy undermine vaccine effectiveness. We therefore need to update our understanding of the immunogenicity of the most recent XBB.
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