Publications by authors named "R BOURGEOIS"
Article Synopsis
- - Leptospirosis, a disease caused by bacteria prevalent mostly in tropical areas, is transmitted through contact with infected rat urine or contaminated environments, with brown rats being key urban reservoirs.
- - A study conducted in Boston from 2016-2022 involved analyzing DNA from 328 rat kidney samples, revealing that 59 rats were positive for leptospirosis and indicating significant genetic structure and limited dispersal among rat populations.
- - The researchers discovered distinct genetic clades of the bacteria linked to specific rat groups, suggesting that rat movement influences the spread of leptospirosis, and indicated a connection between the disease in humans and urban rat populations based on genomic analysis.
Article Synopsis
- The brown dog tick, Rhipicephalus sanguineus s.l., is a significant carrier of Rickettsia rickettsii, which causes Rocky Mountain spotted fever, prompting public health measures to control tick infestations around homes and on pets.
- Current control strategies primarily rely on acaricides, particularly synthetic pyrethroids, but many ticks have developed resistance to these chemicals, complicating prevention efforts.
- Researchers used advanced sequencing techniques to study genetic variations associated with acaricide resistance in different lineages of the tick, finding a specific genetic mutation tied to resistance that was commonly found in tropical lineage ticks across various locations in the US.
Introduction: Despite contemporary practice guidelines, a substantial number of post-acute coronary syndrome (ACS) patients fail to achieve guideline-recommended LDL-C thresholds. Our study aimed to investigate this guideline recommendations-to-practice care gap. Specifically, we aimed to identify opportunities where additional lipid-lowering therapies are indicated and explore reasons for the non-prescription of guideline-recommended therapies.
View Article and Find Full Text PDFBackground: Selecting the appropriate antithrombotic regimen for patients with atrial fibrillation (AF) who have undergone percutaneous coronary intervention (PCI) or have had medically managed acute coronary syndrome (ACS) remains complex. This multi-centre observational study evaluated patterns of antithrombotic therapies utilized among Canadian patients with AF post-PCI or ACS.
Methods And Results: By retrospective chart audit, 611 non-valvular AF patients [median (interquartile range) age 76 (69-83) years, CHADS score 2 (1-3)] who underwent PCI or had medically managed ACS between August 2018 and December 2020 were identified by 68 cardiologists across eight provinces in Canada.
Lipoprotein(a) (Lp(a)) is one of the most important risk factors for the development of calcific aortic valve stenosis (CAVS). However, the mechanisms through which Lp(a) causes CAVS are currently unknown. Our objectives were to characterize the Lp(a) proteome and to identify proteins that may be differentially associated with Lp(a) in patients with versus without CAVS.
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