Publications by authors named "R B Zipursky"
Article Synopsis
- The study aimed to explore plasma levels of the long-acting injectable antipsychotic paliperidone palmitate in outpatients with schizophrenia and its connection to subjective experiences and side effects.
- Blood samples from 21 patients indicated a strong correlation in paliperidone levels across two visits, with the average level being 34.9 ng/ml.
- Results showed that higher paliperidone levels correlated with elevated prolactin levels and decreased sexual desire, but did not significantly relate to the patients' overall experience on the medication or other side effects.
Decline in case rates of youth onset type 2 diabetes in year three of the COVID-19 pandemic.
J Pediatr Endocrinol Metab
April 2024
Objectives: To determine changes in case rates of youth onset type 2 diabetes in the three years following the COVID-19 pandemic.
Methods: A single-center, retrospective medical record review was conducted for patients newly diagnosed with T2D between 3/1/18 and 2/28/23 at a pediatric tertiary care center. The number of patients referred to CHLA with a T2D diagnosis date between 3/1/2020 and 2/28/2023 was compared to historical rates between 3/1/2018 and 2/29/2020.
Schizophrenia spectrum disorders (SSDs) are associated with significant functional impairments, disability, and low rates of personal recovery, along with tremendous economic costs linked primarily to lost productivity and premature mortality. Efforts to delineate the contributors to disability in SSDs have highlighted prominent roles for a diverse range of symptoms, physical health conditions, substance use disorders, neurobiological changes, and social factors. These findings have provided valuable advances in knowledge and helped define broad patterns of illness and outcomes across SSDs.
View Article and Find Full Text PDFAim: We conducted a follow-up analysis of a pilot randomised controlled trial to examine whether baseline depression and anxiety symptoms moderated the impact of a motivational enhancement therapy (MET) pretreatment to dialectical behaviour therapy skill training (DBT-ST) for EA experiencing emotion dysregulation.
Methods: All participants completed a 12-week DBT-ST group intervention and participants in the MET/DBT-ST condition also completed a 4-week group MET pretreatment. Nineteen MET/DBT-ST participants and 26 DBT-ST only participants completed the treatment as per protocol.