[Back pain: patients versus research].

In 2008, approximately 1,559,000 Dutch patients consulted their GP because of back pain. One out of 20 back pain patients is ultimately referred to a specialist, most often to a neurologist. A smaller number (also) go to a neurosurgeon or orthopaedist.

Effect of intra-abdominally induced pressure on the urethral pressure profiles of healthy and incontinent bitches.

Objective: To determine whether reduced pressure transmission is of importance in the pathophysiologic mechanism of urinary incontinence in bitches.

Animals: 20 sexually intact, continent bitches and 21 spayed, incontinent bitches.

Procedure: Urethral pressure profiles before (resting) and after (stressed) insufflation of gas in the abdominal cavity were recorded in bitches under general anesthesia.

[The occurrence of goitrogenic substances in milk. 1. Release of goitrin in the milk of cows fed on rapeseed extract cakes].

A total of six cows, divided into 3 groups, were fed various amounts of rape cake containing 6 g of goitrin/kg over a period of 7 days. The cows were milked twice a day and the goitrin content of the heated milk samples were determined by a HPLC-method within 2 h. When rape cake was fed at 0.

Toxicological assessment of the hemostatic system, regulatory requirements, and industry practice.

Disturbances of the hemostatic system which may be caused by chemicals include hemorrhagic diathesis, caused by inhibition of blood clotting, impairment of platelet function, and hyperactivity of fibrinolysis. Activation of the plasmatic clotting system, platelet aggregation, and inhibition of fibrinolysis may lead to thromboembolic complications. Although much is known about the functions of the hemostatic system a rational and cost-effective approach for its assessment in industrial toxicology is lacking.

Computer generation of dose distributions for a fast-neutron therapy beam.

A system has been developed for the computer generation of dose distributions for the MANTA-NRL fast-neutron radiotherapy beam. This program is based on scatter-air ratio (SAR) techniques. A method has been developed to unfold the effect of the neutron-beam profile in the derivation of SARs so that the SARs obtained are those which would be derived if the beam profile were flat.