Redefining diagnostic lesional status in temporal lobe epilepsy with artificial intelligence.

Despite decades of advancements in diagnostic MRI, 30-50% of temporal lobe epilepsy (TLE) patients remain categorized as "non-lesional" (i.e., MRI negative or MRI-) based on visual assessment by human experts.

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels.

Voltage-gated sodium (Nav) channels are pivotal for cellular signaling, and mutations in Nav channels can lead to excitability disorders in cardiac, muscular, and neural tissues. A major cluster of pathological mutations localizes in the voltage-sensing domains (VSDs), resulting in either gain-of-function, loss-of-function effects, or both. However, the mechanism behind this functional diversity of mutations at equivalent positions remains elusive.

Messenger and message: Uncovering the roles, rhythm and regulation of extracellular vesicles in plant biotic interactions.

Extracellular vesicles (EVs) are membrane-delimited nanoparticles found in every kingdom of life and are known to mediate cell-cell communication in animal systems through the trafficking of proteins and nucleic acids. Research into plant and microbial EVs suggests that these have similar transport capacity, and moreover are able to mediate signalling not only within an organism but also between organisms, acting between plants and their microbial partners in cross-kingdom signalling. Here, we review recent research exploring the roles of these EVs, both plant and microbial, highlighting emerging trends of functional conservation between species and across kingdoms, complemented by the heterogeneity of EV subpopulations at the organism level that places EVs as powerful regulatory mechanisms in plant biotic interactions.

A single-center learning curve for stereotactic laser amygdalohippocampotomy and a surgical framework to manage failures.

Objective: Stereotactic laser amygdalohippocampotomy (SLAH) is a minimally invasive procedure for mesial temporal lobe epilepsy that preserves more tissue than open procedures. As a result, although patients have better functional outcomes, more patients do not achieve seizure freedom. The rate at which this occurs is evolving with improved surgical practices.

Neuroimaging markers of cognitive fatigue in individuals with post-acute sequelae of SARS-CoV-2 infection.

Persistent cognitive fatigue (CF) is the most reported symptom in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), but little is known about its underlying neural basis. This pilot study examined fMRI brain activation patterns during a fatiguing task in those with and without PASC. We hypothesized that individuals with PASC would show changes in CF-related brain activation within fatigue network.