[Screening for celiac disease among patients of the gastroenterological profile].

Aim: To determine the frequency of celiac disease (CD) among gastroenterological patients and criteria for its active detection.

Materials And Methods: 1.358 patients referred for gastroenterologist consultation from 2016 to 2019 was conducted, of which 140 had CD (339 males 24.

[Bile acids are a risk factor for colorectal cancer].

Bile acids were first considered carcinogenic in 1939. Since then, accumulated data have associated colon cell changes with high levels of bile acids as an important risk factor for developing colorectal cancer, which is more common among people who consume large amounts of dietary fat. Secondary bile acids formed under the influence of the intestinal microbiota can cause the formation of reactive forms of oxygen and nitrogen, disruption of the cell membrane, mitochondria, DNA damage, reduction of apoptosis, increased cell mutation, turning them into cancer cells.

Celiac disease associated with ulcerative colitis.

The article provides clinical observation of a patient who was diagnosed with celiac disease when he was 52 years (Marsh stage IIIB). Following gluten-free diet (GFD) clinical remission and restoration of small intestinal mucosa (SIM) structure occurred, however in 6 years ulcerative colitis developed and an impairment of SIM morphological structure was identified (Marsh stage IIIA). Ulcerative colitis and celiac disease remission is supported by GFD, anti-cytokine therapy (adalimumab) in combination with mesalazine.

Is it necessary to use capsular endoscopy to diagnose celiac disease?

Aim: To clarify the indications for capsular endoscopy (CE) in patients with celiac disease.

Materials And Methods: The study included 10 patients with celiac disease (6 women, 4 men) aged 22 to 69 years. The median age was 42.

Mesenchymal stromal cells of bone marrow and azathioprine in Crohn's disease therapy.

Aim: To evaluate the effectiveness of MSCs therapy in patients with CD receiving azathioprine (AZA).

Materials And Methods: The study included 34 patients with inflammatory (luminal) form of CD. The 1st group of patients (n=15) received an- ti-inflammatory therapy using MSCs culture in combination with AZA.