Transdermal estrogen and prevention of osteoporosis.

Transdermal delivery of estrogen is an alternative to the oral route in patients receiving hormone replacement therapy for the prevention of osteoporosis. Both transdermal and oral regimens have been shown to be effective. They can be prescribed as either cyclical or continuous regimens.

[Cytokines in uveal melanoma. Original title: uveal melanoma cytokines].

Cytokines may be important in both the pathophysiology an ocular morbidity associated with treated and untreated uveal melanomas. In this study we used message amplification phenotyping to identify cytokines present in uveal melanoma samples. A number of cytokines were noted that have been associated with tumor progression, neovascularization, and inflammation in other malignancies.

Treatment of adenomyosis with long-term GnRH analogues: a case report.

Presented here is the first reported case of biopsy-proved adenomyosis treated medically with long-term GnRH analogue. Uterine volume, as calculated by serial ultrasound measurements, was reduced by 65% after 4 months and remained small several months after discontinuation of therapy. Size reduction was accompanied by amenorrhea and relief of severe dysmenorrhea.