Publications by authors named "R B Ettenger"
Article Synopsis
- Natural killer (NK) cells play a crucial role in managing both viral infections and immune responses during kidney transplants in children, as shown in a study using data from the CTOTC project.
- The study analyzed NK cell phenotypes in 98 pediatric kidney transplant patients and found specific NK cell traits linked to either viral infections or alloimmune events, such as acute rejection.
- These findings suggest that understanding NK cell profiles could help distinguish between risk factors for infections versus those for immune responses after transplantation.
Introduction: The successes in the field of pediatric kidney transplantation over the past 60 years have been extraordinary. Year over year, there have been significant improvements in short-term graft survival. However, improvements in longer-term outcomes have been much less apparent.
View Article and Find Full Text PDFBackground: Recurrent disease after kidney transplant remains an important cause of allograft failure, accounting for 7-8% of graft loss and ranking as the fifth most common cause of allograft loss in the pediatric population. Although the pathophysiology of many recurrent diseases is incompletely understood, recent advances in basic science and therapeutics are improving outcomes and changing the course of several of these conditions.
Methods: Review of the literature.
Article Synopsis
- This study analyzed how well serum creatinine (Cr) and cystatin C (CysC)-based estimates of glomerular filtration rate (GFR) perform compared to measured GFR (mGFR) in pediatric kidney transplant patients.
- The results indicated that the CysC-based method (Gentian CysC) showed good accuracy and low bias, especially in patients with histological changes, making it a potentially better option for monitoring kidney function.
- Overall, the findings suggest that CysC-based equations could provide more reliable GFR estimates, which can be crucial for early detection and intervention in transplant patients.