Publications by authors named "R B Erdmann"
Article Synopsis
- Myofascial trigger point therapy (MTrP) is used for pain relief, but its mechanisms, including central pain modulation (CPM), are not fully understood; this study explores their potential correlation in healthy individuals.
- The study involved 94 participants subjected to heat and pressure stimuli to assess pain responses before and after MTrP and CPM interventions, systematically measuring mild and intense pressure on specific areas.
- Results indicated a significant correlation between the pain relief from MTrP and CPM, suggesting overlapping mechanisms; the relationship was stronger with more intense stimulation.
Article Synopsis
- The import of proteins into peroxisomes relies on specific proteins: PEX5, PEX13, and PEX14.
- The SH3 domain of PEX13 plays a crucial role in binding to peptide motifs found in PEX5, impacting how these proteins interact.
- Structural studies highlight that these interactions are evolutionarily conserved, and the binding dynamics of these proteins are essential for proper functioning of peroxisomal matrix import.
Article Synopsis
- - Peroxisomes are essential organelles for lipid metabolism and maintaining redox balance in cells, primarily importing matrix proteins via a process that requires ATP but not right at the start.
- - The ATP-dependent phase occurs later in the import process, involving a complex interplay between peroxisomal targeting signal (PTS) receptors and the peroxisomal export complex.
- - Key steps include the monoubiquitination of PTS receptors, facilitating their retrieval from the membrane, and upon deubiquitination, the receptors can help import more proteins into the peroxisome.
PEX1 is essential for glycosome biogenesis and trypanosomatid parasite survival.
Front Cell Infect Microbiol
March 2024
Trypanosomatid parasites are kinetoplastid protists that compartmentalize glycolytic enzymes in unique peroxisome-related organelles called glycosomes. The heterohexameric AAA-ATPase complex of PEX1-PEX6 is anchored to the peroxisomal membrane and functions in the export of matrix protein import receptor PEX5 from the peroxisomal membrane. Defects in PEX1, PEX6 or their membrane anchor causes dysfunction of peroxisomal matrix protein import cycle.
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