Publications by authors named "R B Butler"
Background: The objective of this study was to evaluate the use of telomere length measurements as diagnostic biomarkers during early screening for lung cancer in high-risk patients.
Methods: This was a prospective study of patients undergoing lung cancer diagnosis at two Spanish hospitals between April 2017 and January 2020. Telomeres from peripheral blood lymphocytes were analysed by Telomere Analysis Technology, which is based in high-throughput quantitative fluorescent in situ hybridization.
Background: Alzheimer's disease (AD) therapeutics have largely been unsuccessful in alleviating disease burden in those afflicted by the disease. The TREAT-AD Consortium is an international group of academic researchers dedicated to identifying novel molecular targets for AD from underexplored areas of disease linked pathology.
Method: Utilizing a top-down expert curation approach of organizing Gene Ontology terms into endophenotypes of AD, we developed 19 biological domains.
Introduction: The availability of amyloid beta (Aβ) targeting therapies for Alzheimer's disease (AD) is increasing the demand for scalable biomarkers that are sensitive to early cerebral Aβ accumulation.
Methods: We evaluated fully-automated Lumipulse plasma Aβ/Aβ immunoassays for detecting cerebral Aβ in 457 clinically unimpaired (CU) and clinically impaired (CI) Stanford Alzheimer's Disease Research Center (Stanford ADRC) participants and 186 CU in the Stanford Aging and Memory Study (SAMS). Longitudinal change in ADRC plasma Aβ/Aβ and cognition and cross-sectional associations with SAMS memory and tau positron emission tomography (PET) were examined.
Article Synopsis
- Filopodia, microspikes, and cytonemes are structures in cells that help sense the environment and transport various materials across tissues, built mainly from bundles of actin filaments.
- The study discovered monoclonal antibodies that can elongate filopodia-like structures by targeting a specific part of actin filaments known as the D-loop.
- By preventing actin disassembly, these antibodies provide insights into how the length of filopodia is regulated, suggesting that keeping the actin filament D-loop in an open state promotes longer structures.