Publications by authors named "R B Bourne"
Purpose: Benzodiazepines and z-drugs are often prescribed to critical care survivors due to high prevalence of mental health problems and insomnia. However, their safety has not been studied in this population.
Methods: Retrospective cohort study of 28,678 adult critical care survivors hospitalised in 2010 and 2018: 4844 prescribed benzodiazepines or z-drugs, matched to 23,834 unexposed survivors using UK Clinical Practice Research Datalink linked datasets.
Article Synopsis
- Survivors of critical illness often develop mental health issues and sleep disorders, leading to the study of new benzodiazepine and z-drug prescriptions among these individuals.
- A retrospective study analyzed data from over 52,000 adult survivors who didn't use these medications before hospitalization, finding that 5.2% received a new prescription within 90 days post-discharge and 2.5% had persistent use.
- Key factors associated with new prescriptions included a history of insomnia, anxiety, depression, and recent opioid use, while sex didn't impact prescribing rates and older patients were less likely to be prescribed these medications.
Article Synopsis
- Effective care for critically ill patients in ICU relies on collaboration and communication among healthcare teams, but medication errors during transitions to hospital wards can negatively impact patient outcomes.
- A qualitative study with focus groups aimed to identify necessary changes and develop a theory-informed intervention package to enhance medication safety among ICU patients transitioning to wards.
- The intervention package comprises seven core components for improving medication management, grounded in behavioral change techniques, with specific mechanisms for how each component will enhance patient safety.
Flow synthesis is becoming increasingly relevant as a sustainable and safe alternative to traditional batch processes, as reaction conditions that are not usually achievable in batch chemistry can be exploited (for example, higher temperatures and pressures). Telescoped continuous reactions have the potential to reduce waste by decreasing the number of separate unit operations (e.g.
View Article and Find Full Text PDFDiscontinuation of important chronic medication after hospitalisation is common. This study aimed to investigate the association between critical care (vs non-critical care) admission and discontinuation of chronic medications post-hospital discharge, along with factors associated with discontinuation among critical care survivors. This was a retrospective cohort study in Lothian, Scotland of adults who were admitted to hospital between 01/01/2012 and 31/12/2019 and survived to hospital discharge.
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