Publications by authors named "R B Abdelali"
Cell Stem Cell
February 2023
Article Synopsis
- Patients with Fanconi anemia (FA) show chromosome instability, leading to exhaustion of hematopoietic stem cells and a higher risk of developing poor-prognosis myeloid leukemia.
- A study involving 62 patients revealed unique mutations and structural variants that resemble BRCA-related cancers, with many patients showing chromosome 1q gain linked to MDM4 trisomy, which downregulates p53 signaling.
- MDM4 triplication not only enhances the survival of FA stem cells but also promotes leukemia development, suggesting that targeting MDM4 could be a potential therapeutic strategy to disrupt this pathway.
Article Synopsis
- The study looked at how different gene mutations affect the health of people with myelofibrosis, a type of blood disease.
- Researchers analyzed 479 patients and grouped them based on specific mutations to see how these groups relate to worsening conditions or death.
- They found that mutations in certain genes like TP53 and high-risk genes made it more likely for patients to get worse or die, while a mutation in the ASXL1 gene alone didn’t have a significant negative impact.
Am J Hematol
November 2020
Article Synopsis
- FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare condition with limited epidemiological data; a retrospective study analyzed 151 patients in France from 2003-2019.
- Imatinib mesylate (IM) is very effective, with 98% of treated patients achieving complete hematologic and molecular responses; however, a significant percentage of patients relapsed after stopping IM.
- Factors such as the timing of IM initiation and duration of treatment were identified as independent predictors of relapse, suggesting that early and prolonged treatment may help reduce the chances of relapse.
Biomark Insights
March 2018
Article Synopsis
- MiR-31-3p is identified as a potential biomarker for predicting how well patients with RAS wild-type metastatic colorectal cancer respond to anti-EGFR therapy.
- A new RT-qPCR assay was developed and validated to measure miR-31-3p levels in formalin-fixed paraffin-embedded tumor samples.
- The study confirmed that the assay is reliable, with consistent performance across various conditions and PCR platforms, indicating it's feasible to quantify miR-31-3p in clinical samples.
