Shorebirds Are Shrinking and Shape-Shifting: Declining Body Size and Lengthening Bills in the Past Half-Century.

Animals are predicted to shrink and shape-shift as the climate warms, declining in size, while their appendages lengthen. Determining which types of species are undergoing these morphological changes, and why, is critical to understanding species responses to global change, including potential adaptation to climate warming. We examine body size and bill length changes in 25 shorebird species using extensive field data (> 200,000 observations) collected over 46 years (1975-2021) by community scientists.

A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants.

The Pseudomonas syringae species complex harbors a diverse range of pathogenic bacteria that can infect hosts across the plant kingdom. However, much of our current understanding of P. syringae is centered on its infection of flowering plants.

Kiwifruit spatiotemporal multiomics networks uncover key tissue-specific regulatory processes throughout the life cycle.

Kiwifruit (Actinidia chinensis), a recently commercialized horticultural crop, is rich in various nutrient compounds. However, the regulatory networks controlling the dynamic changes in key metabolites among different tissues remain largely unknown. Here, high-resolution spatiotemporal datasets obtained by ultraperformance liquid chromatography-tandem mass spectrometry methodology and RNA-seq were employed to investigate the dynamic changes in the metabolic and transcriptional landscape of major kiwifruit tissues across different developmental stages, including from fruit skin, outer pericarp, inner pericarp, and fruit core.

Stage-specific pharmacodynamic chloroquine and pyronaridine action on artemisinin ring-stage resistant Kelch C580Y mutation correlates to hemozoin inhibition process.

The antimalarial quinolines pyronaridine and chloroquine both inhibit hemozoin crystallization, predominately produced by intra-erythrocytic trophozoite stage parasites. Pyronaridine extends activity to ring-stage chloroquine-sensitive parasites, in contrast to chloroquine. Here, we investigated chloroquine and pyronaridine hemozoin inhibition type correlated to stage-specific activity on chloroquine-resistant ring-stage artemisinin sensitive and resistant CamWT and CamWT-C580Y parasites.