Publications by authors named "R Astin"

Anti-IgLON5 is a rare condition with a diverse clinical spectrum. Mortality is high with patients developing respiratory compromise secondary to central hypoventilation or upper airway obstruction. Patients often progress to requiring ventilatory support and tracheostomy.

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The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus ("long COVID") is not fully understood. Cases were recruited from a long COVID clinic (N = 32; 44 ± 12 years; 10 (31%) men), and age-/sex-matched healthy controls (HC) (N = 19; 40 ± 13 years; 6 (32%) men) from University College London staff and students. We assessed exercise performance, lung and cardiac function, vascular health, skeletal muscle oxidative capacity, and autonomic nervous system (ANS) function.

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Unlabelled: Significant inconsistencies in respiratory care provision for Duchenne muscular dystrophy (DMD) are reported across different specialist neuromuscular centres in the UK. The absence of robust clinical evidence and expert consensus is a barrier to the implementation of care recommendations in public healthcare systems as is the need to increase awareness of key aspects of care for those living with DMD. Here, we provide evidenced-based and/or consensus-based best practice for the respiratory care of children and adults living with DMD in the UK, both as part of routine care and in an emergency.

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Background: A diagnosis of MND takes an average 10-16 months from symptom onset. Early diagnosis is important to access supportive measures to maximise quality of life. The COVID-19 pandemic has caused significant delays in NHS pathways; the majority of GP appointments now occur online with subsequent delays in secondary care assessment.

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Article Synopsis
  • The review focuses on long COVID, exploring its epidemiology, physiological impacts, underlying mechanisms, and potential treatment strategies, stemming from discussions at a Physiological Society online conference.
  • Key advancements highlighted include improved understanding of long COVID's pathophysiology and cellular mechanisms, as well as therapeutic approaches being trialed for managing the condition.
  • The research emphasizes the connections between long COVID and other post-viral syndromes, suggesting that insights from active populations, like the military and elite athletes, can inform broader strategies for managing long COVID symptoms and improve patient support.
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