Publications by authors named "R Artigiani"
Article Synopsis
- This study investigates the impact of four specific genes (FAM49B, FAM84B, GSDMC, and miR-5194) located in the frequently altered 8q24.21 region on gastric cancer (GC), aiming to shed light on gene expression and copy number variations (CNV) related to GC.
- Analysis involved comparing gene expression in tumoral and adjacent non-tumoral gastric tissues from 51 to 85 cancer patients against control samples from non-cancer individuals, revealing that three of the four genes were upregulated in cancerous tissues.
- The findings suggest that higher expression levels of FAM49B, GSDMC, and miR-
Gastric cancer (GC) is one of the leading types of fatal cancer worldwide. Epigenetic manipulation of cancer cells is a useful tool to better understand gene expression regulatory mechanisms and contributes to the discovery of novel biomarkers. Our research group recently reported a list of 83 genes that are potentially modulated by DNA methylation in GC cell lines.
View Article and Find Full Text PDFGastric cancer (GC) is the third leading cause of cancer-related death worldwide. Very few therapeutic options are currently available in this neoplasia. The use of 5-Aza-2'-deoxycytidine (5-AZAdC) was approved for the treatment of myelodysplastic syndromes, and this drug can treat solid tumours at low doses.
View Article and Find Full Text PDFTo analyze gene expression and copy number of five miRNAs (, , , and ) localized in this chromosome region in gastric cancer (GC). 65 paired neoplastic and non-neoplastic specimens collected from GC patients and 20 non-neoplastic gastric tissues from cancer-free individuals were included in this study. The expression levels of the five miRNAs were accessed by real time qPCR and were correlated.
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