[Treatment of herpes infections with transfer factor].

Twelve patients suffering from recurrent herpetic infections resistant to several current therapies were treated for a 3 to 10 months period with a bovine transfer factor specific to Herpes simplex virus of type 1 and 2. The results obtained showed that this treatment was capable of dramatically reducing the intensity, duration and frequency of the relapses. This preliminary clinical trial suggests that specific transfer factor administered orally could be an effective treatment of herpes infections.

Differential aspects of Solcoderm therapy as a function of dermatologic diagnoses.

Experience with 265 Solcoderm-treated lesions in 131 patients followed for 1 year is the basis of delineating the preferred methods of treating skin tumors with this new caustic agent. General principles and diagnosis-specific suggestions are presented.

[Measurement of sulfoconjugates of 5-androsten-3 beta, 17 beta-diol in idiopathic hirsute virilism].

The sulphoconjugates of delta 5-C19O2 steroids were determined in 32 women with idiopathic hirsutism (IH). The plasma and urinary levels of 5-androsten-3 beta, 17 beta-diol (delta 5, 3 beta-diol) were 82 +/- 24 ng/ml and 169 +/- 170 micrograms/24 h respectively for the monosulphate ester and 193 +/- 101 ng/ml and 180 +/- 108 micrograms/24 h for the disulphate ester. These levels are statistically higher (p less than 0,001) as compared with the levels observed in women without IH (30 +/- 20 ng/ml and 23 +/- 13 micrograms/24 h for the monosulphate, 78 +/- 40 ng/ml and 48,0 +/- 23,7 micrograms/24 h for the disulphate).

[Antiandrogens and acne].

One hundred forty-four patients with acne, in most cases severe, were treated with cyproterone acetate, either at low dose ( Diane : 2 mg daily for 21 days), or at high dose ( Androcur : 50-100 mg daily for 10 days) in an inversed sequential schedule according to Hammerstein . The comparison between the two groups of patients exhibits an highly significant difference in favour of Androcur , as well on seborrhea as on comedones and eruptions, whatever the dose (50 or 100 mg); similarly, the results of Androcur were the same with or without topical treatment (Tretinoin or Benzoyl peroxide). The tolerance was equally good in the two groups.