Evaluation of Vascular Pulse Contour Indices over the Physiological Blood Pressure Ranges in an Anesthetized Porcine Model.

A series of physiological measures can be assessed from the arterial pulse waveform, which is beneficial for cardiovascular health diagnosis, monitoring, and decision making. In this work, we have investigated the variations in regional pulse wave velocity (PWVR) and other pulse waveform indexes such as reflected wave transit time (RWTT), augmentation index (Alx), ejection duration index (ED), and subendocardial viability ratio (SEVR) with blood pressure (BP) parameters and heartrate on a vasoconstrictor drug-induced porcine model. Two healthy female (nulliparous and non-pregnant) Sus scrofa swine (~ 80 kg) was used for the experimental study.

Repeatability Study of Local Vascular Stiffness Measurement Using Carotid Surface Acceleration Plethysmogram.

We have developed an accelerometric system with a custom-designed patch probe and signal acquisition hardware to acquire the carotid wall displacement from the soft tissue surface for arterial stiffness evaluation. A subject-specific calibration model was developed to estimate the morphology of accurate carotid diameter waveform, using a standard ultrasound B-mode imaging system as the reference. Following the one-time calibration, the accelerometric system continuously acquired a non-invasive carotid lumen diameter waveform.

Continuous Assessment of Carotid Diameter using an Accelerometer Patch Probe for Ambulatory Arterial Stiffness Monitoring.

We present a system with an accelerometer patch probe design for non-invasive evaluation of carotid arterial stiffness. The proposed system could continuously measure the acceleration signal derived due to the propagation of blood pulse wave through the left carotid artery, double integrating and scaling it to estimate the accelerometer-derived carotid wall displacement. This functional principle was proved by comparing the accelerometer-derived carotid wall displacement with the carotid distension signal from the reference system ARTSENS® (ARTerial Stiffness Evaluation for Noninvasive Screening device) for all the recruited human subjects.

Carotid Local Pulse Wave Velocity Measurement using Dual- Element Accelerometric Patch Probe.

In this work, we demonstrate an accelerometric patch probe with two microelectromechanical accelerometer sensors for local pulse wave velocity (PWV) measurement from the carotid artery. Dual acceleration plethysmogram (APG) signals were acquired from a small section of the artery by keeping the sensors at 32 mm apart. A custom analog front-end circuit (inter-channel delay $< 0.