Publications by authors named "R Appeltant"
Article Synopsis
- Wildlife biodiversity helps keep ecosystems healthy and strong.
- Scientists study this diversity to learn more about life and how it started.
- Due to the rapid loss of various species, immediate action is needed from conservationists, and new techniques like stem cell technologies could help protect animal diversity.
Article Synopsis
- Cloning in the animal kingdom involves creating genetically identical individuals and is gaining attention for its potential in conserving endangered or extinct species.
- Various reproductive techniques, including somatic cell nuclear transfer and induced pluripotent stem cells, expand our understanding of cloning's role in conservation beyond traditional methods.
- Ethical considerations and practical implications must be evaluated alongside biological advancements to assess the viability of cloning in protecting endangered species.
The northern white rhinoceros is functionally extinct with only two females left. Establishing methods to culture ovarian tissues, follicles, and oocytes to generate eggs will support conservation efforts using in vitro embryo production. To the best of our knowledge, this is the first description of the structure and molecular signature of any rhinoceros, more specifically, we describe the neonatal and adult southern white rhinoceros (Ceratotherium simum simum) ovary; the closest relation of the northern white rhinoceros.
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- - Cloning involves creating genetically identical individuals and has varied definitions over time, from natural reproduction in bacteria to advanced molecular techniques in vertebrates.
- - Key methods for mammalian cloning include embryo splitting, somatic cell nuclear transfer, and using induced pluripotent stem cells, with emerging biotechnologies enhancing genome propagation.
- - This review focuses on the current cloning technologies and their potential applications in conserving endangered animal species, moving beyond human and rodent research models.
Article Synopsis
- Mitochondrial quality declines with age, affecting female fertility, prompting a study on mitochondrial RNA transcripts in mouse oocytes and cumulus cells across different age groups.
- No significant age-related differences in mitochondrial transcripts were found, but variations were more frequent in cumulus cells compared to oocytes.
- The findings suggest either oocytes experience less post-transcriptional modification or they have a lower mtDNA mutational load compared to cumulus cells.