Publications by authors named "R Anjali Krishnan"
The rise in the global population has increased the demand for dietary food protein. Strategies to maximize agricultural and livestock outputs could strain land and freshwater supply and contribute to substantial negative environmental impacts. Consequently, there has been an emphasis on identifying alternative sources of edible proteins that are more sustainable, sustainable, ethical, and healthy.
View Article and Find Full Text PDFOrganophosphorus poisoning poses a significant health threat, often resulting in high mortality and disability. The intermediate syndrome, characterized by muscle weakness in neck flexors and limbs, is prevalent. While uncommon, cases of vocal cord paralysis have been observed.
View Article and Find Full Text PDFThe emergence of SARS-CoV-2 variants presents challenges to vaccine effectiveness, underlining the necessity for next-generation vaccines with multiple antigens beyond the spike protein. Here, we investigated a multiantigenic booster containing spike and a chimeric construct composed of nucleoprotein (N) and membrane (M) proteins, comparing its efficacy to a spike-only booster against Omicron BA.5 in K18-hACE2 mice.
View Article and Find Full Text PDFArticle Synopsis
- - The airway smooth muscle (ASM) cell's function in contraction and remodeling relies on changes in its cytoskeleton, shifting between a relaxed "fluid-like" state and a contractile "solid-like" state based on protein interactions.
- - The review explores the roles of various cytoskeletal components, such as actin and myosin, as well as factors that influence their behavior and how these interactions relate to the airway's extracellular matrix and the physical mechanics of airway movement.
- - The findings highlight new insights into the mechanisms of ASM cell activity, which could inform approaches to understanding and treating asthma-related airway obstruction.
Article Synopsis
- Intra and inter-pathologist variability complicates the evaluation of metabolic dysfunction-associated steatohepatitis (MASH) biopsy results, hindering patient selection and assessment quality in clinical trials.
- A study analyzed 120 histology slides with and without AI assistance to evaluate its impact on pathologists' reliability in fibrosis staging, especially for early fibrosis stages.
- Results showed that AI assistance significantly improved concordance among pathologists, increasing agreement rates for clinical trial inclusion and exclusion, which could enhance the overall efficiency and reliability of MASH-related clinical research.