Publications by authors named "R Andrew Roland"

Unlabelled: Rapid identification of methicillin-susceptible (MSSA) bacteremia may optimize antibiotic use and clinical outcomes. The study objective was to assess the impact of the BioFire® blood culture identification (BCID) polymerase chain reaction (PCR) panel on antibiotic use and clinical outcomes in patients with MSSA bacteremia. This was a retrospective chart review of adult inpatients with MSSA bacteremia during the pre-PCR (June 2018-December 2019) and post-PCR (June 2020-December 2021) implementation periods.

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Article Synopsis
  • - The study evaluated the impact of the BioFire® FilmArray® blood culture identification panels on the time to optimal therapy (TTOT) for bacteremia caused by specific organisms at two community hospitals.
  • - Results showed no significant differences in overall TTOT between groups before and after implementing the BCID panels, but BCID2 saw more timely therapy adjustments and effective carbapenem use for gram-negative bacteria.
  • - There was also a notable decrease in the length of vancomycin treatment for gram-positive bacteria after BCID2 was implemented, indicating improved antimicrobial prescribing practices.
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Shedding light on the validity of sentence completion test (SCT) verbal defensiveness as an index of defensive behavior, the current two-part study examined the relationship between psychological threat and verbal defensiveness among military security and mission-critical team candidates using SCTs. Our study showed that as the threatening nature of SCT stems increased, defensive responses also increased, substantiating the link between psychological threat and defensive behavior. In addition, expert ratings of stem content revealed moderately strong relationships with defensive responses across two different SCTs, irrespective of their structural characteristics.

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Depression presents a significant global health burden, necessitating the search for effective and safe treatments. This investigation aims to assess the antidepressant effect of the hydroethanolic extract of (AO) on depression-related behaviors in rats. The depression model involved 42 days of unpredictable chronic mild stress (UCMS) exposure and was assessed using the sucrose preference and the forced swimming (FST) test.

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