Publications by authors named "R Anchan"
Endometriosis is a debilitating and painful gynecological inflammatory disease affecting up to 15% of women and transgender men. Current treatments are ineffective for a substantial proportion of patients, underscoring the need for additional therapies with long-term benefits. Nociceptors release neuropeptides, such as calcitonin gene-related peptide (CGRP), which are known to shape immunity through neuroimmune communication.
View Article and Find Full Text PDFObjective: To evaluate implementation of a patient decision aid for symptomatic uterine fibroid management to improve shared decision-making at five clinical settings across the United States.
Methods: We used a type 3 hybrid effectiveness-implementation stepped-wedge design and the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) planning and evaluation framework. We conducted clinician training, monthly reach tracking with feedback to site clinical leads, patient and clinician surveys, and visit audio-recordings.
Article Synopsis
- Hydroxyapatite (HA) is a widely used material in dental and orthopedic fields due to its compatibility with biological tissues and its ability to mimic bone properties, making it a popular choice for bone-graft substitutes.
- This study specifically explored the use of HA derived from goat bones and teeth, utilizing thermal calcination, and assessed its potential for commercial use through various chemical characterization techniques and biocompatibility tests with different cell lines.
- While HA derived from sheep, goat, and caprine sources shows promise in applications such as antimicrobial activity and wound healing, more research is needed to fully harness these materials for bone graft substitutes and tap into sustainable production methods.
Article Synopsis
- Fibroids are non-cancerous growths in the uterus that can negatively affect quality of life, prompting the need for personalized treatment options and better communication tools for shared decision-making among patients and healthcare providers.* -
- A user-centered approach was used to develop two conversation aids—one text-based and one picture-enhanced—through stakeholder focus groups and user-testing interviews, with efforts made to translate them into Spanish simultaneously.* -
- Initial feedback from focus groups and user-testing showed the conversation aids were well-received, but ongoing implementation revealed the need for significant updates to reflect new treatment information and accommodate stakeholder suggestions.*
Introduction: Endometriosis is a chronic inflammatory disease that affects ∼10 % of women. A significant fraction of patients experience limited or no efficacy with current therapies. Tissue adjacent to endometriosis lesions often exhibits increased neurite and vascular density, suggesting that disease pathology involves neurotrophic activity and angiogenesis.
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