Lysophosphatidylcholine induces ceramide synthase-2 expression in primary culture model of astrocytopathy: potential therapeutic target in multiple sclerosis.

Background: Multiple sclerosis (MS) is a chronic autoimmune condition that damages the myelin sheath of neurons in the central nervous system, resulting in compromised nerve transmission and motor impairment. The astrocytopathy is considered one of the prominent etiological factor in the pathophysiology of demyelination in MS. The expression level of ceramide synthase-2 (CS-2) is yet to be established in the pathophysiology of astrocytopathy although the derailed ceramide biosynthetic pathways is well demonstrated in the pathophysiology of demyelination.

Sustainable, greenhouse gas derived fermented protein in canine diets-a pilot study.

Sustainability concerns have increased consumer demand for non-animal-derived proteins and the search for novel, alternative protein sources. The nutritional sustainability of the food system without compromising the nutrient quality, composition, digestibility and consumption is pivotal. As with farmed livestock, it is imperative to ensure the well-being and food security of companion animals and to develop sustainable and affordable pet foods.

Design, safety and efficacy evaluation of gemcitabine-eluting nanoyarn-integrated heparinized self expanding metallic stents for long-term management of malignant biliary obstruction.

Malignant biliary obstruction presents a significant therapeutic challenge and has serious consequences including cholangitis and death. Clinically, biliary stenting using self-expanding metallic- stent(SEMS) relieves this obstruction. However, stent occlusion occurs with time due to tumor/epithelial in-growth and bacterial colonization.

Current opinion on pluripotent stem cell technology in Gaucher's disease: challenges and future prospects.

Gaucher's disease (GD) is a rare autosomal recessive genetic disorder caused by mutations in the gene. Mutations in the gene lead to the deficiency of glucocerebrosidase, an enzyme that helps in the breakdown of glucosylceramide (GlcCer) into ceramide and glucose. The lack of the enzyme causes GlcCer accumulation in macrophages, resulting in various phenotypic characteristics of GD.

Nanocomposite based slow release atrazine effectively controlled Striga asiatica incidence, and enhanced sugarcane yield.

Sugarcane is a major industrial crop highly susceptible to parasitic weed (Striga spp.), causing a 38% reduction in cane yield due to a longer lag phase of 20-40 days, and wider spacing. Herbicides with a longer retention and slow-release nature could allow Striga seeds to germinate and be killed before attaching to the host.