Significant challenges to the sustainability of the California coast considering climate change.

Climate change is an existential threat to the environmental and socioeconomic sustainability of the coastal zone and impacts will be complex and widespread. Evidence from California and across the United States shows that climate change is impacting coastal communities and challenging managers with a plethora of stressors already present. Widespread action could be taken that would sustain California's coastal ecosystems and communities.

Hermetic Bags: A Short-Term Solution to Preserve High-Moisture Maize during Grain Drying.

Maintaining maize quality while drying during a rainy season is a major challenge for smallholder farmers in developing countries. We conducted a study to evaluate the impact of temporarily storing wet maize of 18, 21, and 24% moisture content (m.c.

Treatment with the PPARα agonist fenofibrate improves the efficacy of CD8 T cell therapy for melanoma.

Adoptive transfer of tumor antigen-specific CD8 T cells can limit tumor progression but is hampered by the T cells' rapid functional impairment within the tumor microenvironment (TME). This is in part caused by metabolic stress due to lack of oxygen and glucose. Here, we report that fenofibrate treatment of human expanded tumor-infiltrating lymphocytes (TILs) improves their ability to limit melanoma progression in a patient-derived xenograft (PDX) mouse model.

Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death.

Human norovirus is the leading cause of acute gastroenteritis worldwide, however despite the significance of this pathogen, we have a limited understanding of how noroviruses cause disease, and modulate the innate immune response. Programmed cell death (PCD) is an important part of the innate response to invading pathogens, but little is known about how specific PCD pathways contribute to norovirus replication. Here, we reveal that murine norovirus (MNV) virus-induced PCD in macrophages correlates with the release of infectious virus.