Publications by authors named "R Ally Speight"
Article Synopsis
- Large-scale studies are essential to investigate the gut microbiota's complex relationships with health and disease, and tissue preservation methods need evaluation for feasibility in such research.
- Biopsies from 20 adults with inflammatory bowel disease were preserved using three methods: flash freezing, nucleic acid preservative reagents, and formalin fixation with paraffin embedding (FFPE), with microbiota analyzed using sequencing.
- Results showed that while preservative reagents can serve as viable alternatives to flash freezing, FFPE samples exhibited distinct community structures, highlighting the potential utility of historical samples despite differences in microbial profiles.
Article Synopsis
- This study focused on optimizing CBCT protocols for head and neck radiotherapy using a 3D-printed phantom to improve patient positioning and reduce radiation dose.
- Ten different CBCT protocols were tested, revealing that some protocols could cut radiation exposure by over 50% while still providing good image quality for treatment setup.
- The research highlights the need for tailored imaging protocols based on the area being treated, indicating that future work is required to further refine these protocols for adaptive radiotherapy and to establish effective dose measurements.
This study aims to identify and evaluate suitable and stable materials for developing a head and neck anthropomorphic multimodality phantom for radiotherapy purposes. These materials must mimic human head and neck tissues in both computed tomography (CT) and magnetic resonance imaging (MRI) and maintain stable imaging properties over time and after radiation exposure, including the high levels associated with linear accelerator (linac) use.Various materials were assessed by measuring their CT numbers and T1 and T2 relaxation times.
View Article and Find Full Text PDFEngineered strains of Yarrowia lipolytica with modified lipid profiles and other desirable properties for microbial oil production are widely reported but are almost exclusively characterized in synthetic laboratory-grade media. Ensuring translatable performance between synthetic media and industrially scalable lignocellulosic feedstocks is a critical challenge. Yarrowia lipolytica growth and lipid production were characterized in media derived from two-step acid-catalyzed glycerol pretreatment of sugarcane bagasse.
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