Publications by authors named "R Allen Gorman"

Artificial intelligence (AI) can enhance life experiences and present challenges for people with disabilities. This study aims to investigate the relationship between AI and disability, exploring the potential benefits and challenges of using AI for people with disabilities. A systematic scoping review was conducted using eight online databases; 45 scholarly articles from the last 5 years were identified and selected for thematic analysis.

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This scoping review examines current research on AI for inclusive design for people with disabilities. We identified both advantages and challenges of AI-based solutions and suggested future research directions. Our search of four online databases for studies from the last five years revealed promising AI applications in education, daily living, home environments, workplaces, and healthcare.

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Yolk sac macrophages are the first to seed the developing heart, however we have no understanding of their roles in human heart development and function due to a lack of accessible tissue. Here, we bridge this gap by differentiating human embryonic stem cells (hESCs) into primitive LYVE1 macrophages (hESC-macrophages) that stably engraft within contractile cardiac microtissues composed of hESC-cardiomyocytes and fibroblasts. Engraftment induces a human fetal cardiac macrophage gene program enriched in efferocytic pathways.

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Ischemic mitral regurgitation (IMR) occurs from incomplete coaptation of the mitral valve (MV) after myocardial infarction (MI), typically worsened by continued remodeling of the left ventricular (LV). The importance of LV remodeling is clear as IMR is induced by the post-MI dual mechanisms of mitral annular dilation and leaflet tethering from papillary muscle (PM) distension via the MV chordae tendineae (MVCT). However, the detailed etiology of IMR remains poorly understood, in large part due to the complex interactions of the MV and the post-MI LV remodeling processes.

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Viral encephalitis is a rare, yet severe neurological disorder. It poses a significant public health threat due to its high morbidity and mortality. Despite the disproportionate burden of the disease in impoverished African countries, the true extent of the problem remains elusive due to the scarcity of accurate diagnostic methods.

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