ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction.

Myocardial infarction (MI) compromises the cardiac microvascular endothelial barrier, increasing leakage and inflammation. HIF2α, predominantly expressed in cardiac endothelial cells during ischemia, has an unclear role in barrier function during MI. Here, we show that inducible, adult endothelial-specific deletion of Hif2α in mice leads to increased mortality, cardiac leakage, inflammation, reduced heart function, and adverse remodeling after MI.

miRNA-19a-3p Exacerbates Tube Formation by Targeting SOCS1 to Regulate JAK2/STAT3/VEGF in Diabetic Retinopathy.

Objective: Diabetic retinopathy (DR) is a retinal microangiopathy caused by diabetes mellitus. miRNAs have been shown to be involved in DR-associated micro vessel formation, influence the DR progression, and may be a therapeutic strategy for DR. miRNA-19a-3p is highly expressed in the vitreous of DR patients, however, its mechanism in the occurrence and development of DR is unclear.

Effects of okadaic acid on Pyropia yezoensis: Evidence from growth, photosynthesis, oxidative stress and transcriptome analysis.

The frequent occurrences of harmful algal blooms potentially threaten marine organisms. The phycotoxin okadaic acid (OA) has been globally detected in seawater, however, the knowledge of effects of OA on macroalgae is limited. This study investigated the effects of OA (0.

Synthesis and chromatographic evaluating of the core-shell SiO with tunable shell thickness and application for separation of Traditional Chinese Medicine oligosaccharides.

The development of core-shell materials for achieving more efficient and rapid chromatographic separations has remained a key objective in separation science. In this study, monodisperse SiO particles (2-4 µm in diameter) were utilized to fabricate core-shell spheres through a combined approach involving a modified sol-gel process and a biphasic system. The synthesis employed 1,6-bis(triethoxysilyl) hexane (BTMSH), 1,2-bis(triethoxysilyl) ethane (BTEE) as a bridging agent with cetyltrimethylammonium bromide (CTAB) acting as a co-template.

The value of MRI radiomics in distinguishing different types of spinal infections.

Background: In clinical practice, the three most prevalent forms of infectious spondylitis are tuberculous spondylitis (TS), brucellosis spondylitis (BS), and pyogenic spondylitis (PS). It is possible to successfully lessen neurological and spinal damage by detecting them early. In the medical field, radiomics has been applied extensively.