Genetic and epigenetic characterization of sarcoma stem cells across subtypes identifies EZH2 as a therapeutic target.

High-grade soft tissue sarcomas (STS) are a heterogeneous and aggressive set of cancers. Failure to respond anthracycline chemotherapy, standard first-line treatment, is associated with poor outcomes. We investigated the contribution of STS cancer stem cells (STS-CSCs) to doxorubicin resistance.

Biomarkers.

Background: Approximately 10% of patients with acute SARS-CoV-2 infection present with persistent symptoms recognized as the long-COVID. Neurological and cognitive symptoms are prevalent in long-COVID, requiring a deeper understanding of the biological basis of this condition for potential therapeutic interventions. Cerebrovascular complications are observed during acute infection, underscoring the importance of understanding cerebrovascular outcomes.

Developing Topics.

Background: Digital cognitive tools offer novel ways to detect early cognitive changes associated with preclinical Alzheimer's disease (AD). A digital version of the maze test (dMaze) was recently developed using a digital pen (12 ms temporal precision) to uniquely capture the process of test completion, reflecting the thinking effort, potentially more sensitive to early cognitive deficits in preclinical AD. The sensitivity of these novel digital maze test variables-Wall Penetration Count and Speed Standard Deviation (Speed SD)-to detect early amyloid-β burden was evaluated, hypothesizing that greater amyloid accumulation would be associated with greater variability of speed, and more wall penetration errors while completing the task, reflecting a greater thinking effort.

Alzheimer's Imaging Consortium.

Background: Approximately 10% of patients with acute SARS-CoV-2 infection present with persistent symptoms recognized as the long-COVID. Neurological and cognitive symptoms are prevalent in long-COVID, requiring a deeper understanding of the biological basis of this condition for potential therapeutic interventions. Cerebrovascular complications are observed during acute infection, underscoring the importance of understanding cerebrovascular outcomes.

The Trifecta of Industry, Academic, and Health System Partnership to Improve Mental Health Care Through Smartphone-Based Remote Patient Monitoring: Development and Usability Study.

Background: Mental health treatment is hindered by the limited number of mental health care providers and the infrequency of care. Digital mental health technology can help supplement treatment by remotely monitoring patient symptoms and predicting mental health crises in between clinical visits. However, the feasibility of digital mental health technologies has not yet been sufficiently explored.