Publications by authors named "R Albin"
Visual and visual processing deficits are implicated in freezing, falling, and cognitive impairments in Parkinson's disease (PD). In particular, contrast sensitivity deficits are common and may be related to cognitive impairment in PD. While dopaminergic deficits play a role in PD-related visual dysfunction, brain cholinergic systems also modulate many aspects of visual processing.
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- - Adults with Down syndrome are genetically prone to developing Alzheimer's disease after 40, and their cholinergic system, crucial for cognitive function, shows a decline similar to Alzheimer's pathology.
- - A study using PET imaging compared cholinergic terminals in 16 non-demented adults with Down syndrome to 20 neurotypically developed individuals, focusing on brain areas like the cerebellum and cortex.
- - Results revealed that adults with Down syndrome had higher cholinergic terminal density in early adulthood, but experienced a faster decline with age compared to their neurotypical counterparts.
Background: With bipolar disorder (BD) having a lifetime prevalence of 4.4% and a significant portion of patients being chronically burdened by symptoms, there has been an increased focus on uncovering new targets for intervention in BD. One area that has shown early promise is the mitochondrial hypothesis.
View Article and Find Full Text PDFIntroduction: A recently developed mild behavioral impairment (MBI) diagnostic framework standardizes the early characterization of neuropsychiatric symptoms in older adults. However, the joint contributions of Alzheimer's disease (AD) pathology and brain function to MBI remain unclear.
Methods: We test a novel model assessing direct relationships between AD biomarker status and MBI symptoms, as well as mediated effects through segregation of the salience and default-mode networks, using data from 128 participants with diagnosis of amnestic mild cognitive impairment or mild dementia-AD type.
Background: Postural instability and gait disturbances (PIGD) represent a significant cause of disability in Parkinson's disease (PD). Cholinergic system dysfunction has been implicated in falls in PD. The occurrence of falls typically results in fear of falling (FoF) that in turn may lead to poorer balance self-efficacy.
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