Publications by authors named "R Alamar"
Article Synopsis
- PM-allergoids are new vaccines designed to target dendritic cells and induce Treg cells, with this study focusing on their safety and optimal dosage for treating house dust mite allergies in humans.
- In a clinical trial with 196 participants, doses of PM-HDM were compared against placebos using various administration routes (subcutaneous and sublingual) over four months, measuring key outcomes like nasal provocation tests and symptom scores.
- Results showed that PM-HDM was safe, with significant improvements in allergy symptoms observed at higher doses, particularly at 3000 mTU for sublingual administration and 5000 mTU for subcutaneous administration.
Spanish Guidelines for Diagnosis, Management, Treatment, and Prevention of DRESS Syndrome.
J Investig Allergol Clin Immunol
May 2021
Background And Objective: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a complex multisystemic severe drug hypersensitivity reaction whose diagnosis and management are troublesome. DRESS syndrome requires management by various specialists. The correct identification of the culprit drug is essential to ensure safe future therapeutic options for the patient.
View Article and Find Full Text PDFThe introduction of new diagnostic and therapeutic procedures involving allergen exposure may increase the risk of allergic reactions. We designed and distributed an anonymous questionnaire among the allergy units of the Valencian Community in order to collect information on measures to ensure clinical safety. Twelve hospital outpatient clinics and 8 ambulatory care centres reported similar patterns of activities, including the use of critical care units, emergency rooms or day hospitals for higher risk techniques.
View Article and Find Full Text PDFChanges in the prevalence of asthma and chronic rhinitis in Valencia, Spain: the ORBA project 1983-2003.
J Investig Allergol Clin Immunol
May 2014
Background: The physiochemical modification of allergens to reduce allergenicity, while retaining immunogenicity, provides a chance for the administration of higher doses of immunotherapy, with a decreased risk of systemic reactions.
Objective: To evaluate the safety of doses of depigmented glutaraldehyde-polymerized vaccine of Dermatophagoides pteronyssinus increasing those used in normal clinical conditions in comparison with regular doses of a non-modified vaccine.
Materials And Methods: The study was double-blind, parallel and included two patient groups.