Publications by authors named "R Al-Nounou"
Background: Laboratory hematological tests are widely used in clinical practice to assess health and disease conditions. Reference ranges provided by laboratory reports are considered the most authoritative medical tools to assist in the decision-making phase. International standards institutes recommend that reference ranges be established for each region.
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- Myelodysplastic syndrome (MDS) is a challenging blood disorder linked to ineffective blood cell production and difficulty diagnosing due to vague symptoms and unclear criteria.
- Researchers analyzed medical records of 183 patients with severe cytopenias at a Saudi Arabian hematology lab from 2009 to 2016 to improve diagnosis of MDS.
- The study found that MDS was diagnosed in over half of the adult patients, revealing various subtypes and a high rate of specific chromosome abnormalities, highlighting the complexity and diagnostic challenges of the condition.
Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding disorder. Around 490 mutations in and genes were reported. We aimed to use targeted next-generation sequencing (NGS) to identify variants in patients with GT.
View Article and Find Full Text PDFBilateral, simultaneous optic nerve sheath infiltration as a manifestation of leukemia relapse is very rare. A 45-year-old woman with chronic myelogenous leukemia was successfully treated to cytogenetic bone marrow remission 1 year previously and maintained on imatinib. She developed total bilateral blindness with marked, bilateral optic disc edema and evidence of bilateral optic nerve infiltration on magnetic resonance imaging.
View Article and Find Full Text PDFBackground: Glanzmann thrombasthenia (GT) is a rare inherited platelet disorder that is characterized by spontaneous or postprocedural bleeding. The diagnosis of GT depends on identifying the dysfunction of the platelets.
Aim: The aim of this study was to compare a whole blood impedance Multiplate analyzer (MEA) with the standard method, light transmission aggregometry (LTA) in diagnosis of GT.